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Guanylate cyclase (EC 4.6.1.2, also known as guanyl cyclase, guanylyl cyclase, or GC) is a lyase enzyme that converts guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP) and pyrophosphate. It is often part of the G protein signaling cascade that is activated by low intracellular calcium levels and inhibited by high intracellular calcium levels. In response to calcium levels, guanylate cyclase synthesizes cGMP from GTP. cGMP keeps cGMP-gated channels open, allowing for the entry of calcium into the cell.
Like cAMP, cGMP is an important second messenger that internalizes the message carried by intercellular messengers such as peptide hormones and nitric oxide and can also function as an autocrine signal. Depending on cell type, it can drive adaptive/developmental changes requiring protein synthesis. In smooth muscle, cGMP is the signal for relaxation, and is coupled to many homeostatic mechanisms including regulation of vasodilation, vocal tone, insulin secretion, and peristalsis. Once formed, cGMP can be degraded by phosphodiesterases, which themselves are under different forms of regulation, depending on the tissue.
referenceFull Form | Category |
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Southern Galaxy Catalogue | Academic & Science |
Solid Ground Curing | Academic & Science |
Sociedad Geográfica de Colombia | Academic & Science |
Geographical Society of Colombia | Academic & Science |
Genetics Society of Chile | Academic & Science |
Sociedad de Genética de Chile | Academic & Science |
Surgut | Airport Code |
Security Guidance Centre | Business |
Studio Griz Corporation | Business |
Sportscard Guarantee Corporation | Business |
Screen Gems Columbia | Business |
Superior Uniform, Inc., of Florida | Business |
Supplier Group Company | Business |
Stanford Group Company | Business |
Stagecoach Group, P.L.C. | Business |
Sportscard Guaranty Corporation | Business |
School Graduation Certificate | Business |
Soluble Guanylyl Cyclase | Chemistry |
Salem Government Channel | Community |
Slavic Gospel Church | Community |
Southern Gables Church | Community |
Sovereign Grace Church | Community |
Spratley Gifted Center | Community |
Summer Group Cruise | Community |
Savage Gaming Community | Community |
ScrewAttack Gaming Convention | Computing |
Scsi Graphic Command | Computing |
Signaling Gateway Controller | Computing |
Standard Graphics Connect | Computing |
Symantec Ghost Corporate | Computing |
Software Global Consultancy | Computing |
Sudan Gold Coin | Cryptocurrency |
SAFEGAME CASH | Cryptocurrency |
South Georgia College | Educational Institute |
Scottsdale Gun Club | General |
Supreme Grand Champion | General |
Star Gate Command | General |
Sad Girls Club | General |
Superior Group of Companies | General |
Seiritsu Global Center | General |
Solving Global Challenges | General |
Soluble Guanylate Cyclase | General |
Sebaceous Gland Carcinoma | General |
Stop at Railroad Grade Crossings | General |
Solid Gold Cadillac | General |
Storm Games Clan | General |
Specialized Goza Cutter | General |
Superannuation Guarantee Charge | General |
Serial Graphics Controller | General |
Splitter Gruppen Core | General |
Système de Gestion de Contenu | General |
Social Gathering Clothing | General |
Space Generation Congress | General |
Super Game Cartridge | General |
Scranton Gillette Communications | General |
Sarens Giant Crane | General |
Soft gels capsules | General |
Surveyor of Green County | Governmental |
State Government Corporations | Governmental |
Student Governance Council | Governmental |
Student Governing Council | Governmental |
Strategic Growth Council | Governmental |
School Governance Councils | Governmental |
SAONGI | Indian Railway Station |
Structural Genomics Consortium | Medical |
Swan-Ganz Catheter | Medical |
Single Glass Capillary | Medical |
Silicon Graphics Crimson | Military and Defence |
Select Grouped Controls | Military and Defence |
Server-gated Cryptography | Networking |
Surgut, Russia | Regional |
Stabilized Ground Cloud | Space Science |
Schaumburg Golf Club | Sports |
Springhouse Golf Club | Sports |
Posted on 28 Apr 2022, this text provides information on Miscellaneous in Chemistry related to Chemistry. Please note that while accuracy is prioritized, the data presented might not be entirely correct or up-to-date. This information is offered for general knowledge and informational purposes only, and should not be considered as a substitute for professional advice.
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