Buspirone, sold under the brand name Buspar, among others, is a medication primarily used to treat anxiety disorders, particularly generalized anxiety disorder. Benefits support its short-term use. It is taken by mouth, and it may take up to four weeks to have an effect.
Common side effects of buspirone include nausea, headaches, dizziness, and difficulty concentrating. Serious side effects may include hallucinations, serotonin syndrome, and seizures. Its use in pregnancy appears to be safe but has not been well studied, while use during breastfeeding is not recommended. It is a serotonin 5-HT1A receptor agonist.
Buspirone was first made in 1968 and approved for medical use in the United States in 1986. It is available as a generic medication. In 2019, it was the 76th most-commonly prescribed medication in the United States, with more than 9 million prescriptions.
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