CMPI meaning in Medical ?

Answer:

What is Cow's milk protein intolerance mean?

Milk allergy is an adverse immune reaction to one or more proteins in cow's milk. When allergy symptoms occur, they can occur rapidly or have a gradual onset. The former may include anaphylaxis, a potentially life-threatening condition which requires treatment with epinephrine among other measures. The latter can take hours to days to appear, with symptoms including atopic dermatitis, inflammation of the esophagus, enteropathy involving the small intestine and proctocolitis involving the rectum and colon.

In the United States, 90% of allergic responses to foods are caused by eight foods, with cow's milk being the most common. Recognition that a small number of foods are responsible for the majority of food allergies has led to requirements to prominently list these common allergens, including dairy, on food labels. One function of the immune system is to defend against infections by recognizing foreign proteins, but it should not over-react to food proteins. Heating milk proteins can cause them to become denatured, meaning to lose their 3-dimensional configuration, and thus lose allergenicity; for this reason dairy-containing baked goods may be tolerated while fresh milk triggers an allergic reaction.

Management is by avoiding eating any dairy foods or foods that contain dairy ingredients. In people with rapid reactions (IgE-mediated milk allergy), the dose capable of provoking an allergic response can be as low as a few milligrams, so recommendations are to avoid dairy strictly. The declaration of the presence of trace amounts of milk or dairy in foods is not mandatory in any country, with the exception of Brazil.

Milk allergy affects between 2% and 3% of babies and young children. To reduce risk, recommendations are that babies should be exclusively breastfed for at least four months, preferably six months, before introducing cow's milk. If there is a family history of dairy allergy, then soy infant formula can be considered, but about 10 to 15% of babies allergic to cow's milk will also react to soy. The majority of children outgrow milk allergy, but for about 0.4% the condition persists into adulthood. Oral immunotherapy is being researched, but it is of unclear benefit.

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