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What is fibronectin binding protein A mean?
Fibronectin binding protein A (FnBPA) is a Staphylococcus aureus MSCRAMM cell surface-bound protein that binds to both fibronectin and fibrinogen.
It is an adhesin which enables Staphylococcus aureus (S. aureus) to adhere to host cells of another organism, and an invasin facilitating its internalisation into these cells. This is true over a range of different cell types. The FnBP alone is capable of providing this invasive property, without the requirement of co-receptors. Even FnBP coated beads have been shown to become internalised into cells
S. aureus is able to bind to host cells in the absence of the FnBP, but its adherence and invasive properties are much reduced (up to a 500-fold decrease in number of internalised cells)
referencePosted on 25 Dec 2024, this text provides information on Miscellaneous in General related to General. Please note that while accuracy is prioritized, the data presented might not be entirely correct or up-to-date. This information is offered for general knowledge and informational purposes only, and should not be considered as a substitute for professional advice.
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