ISCO meaning in Space Science ?

Answer:

What is Innermost Stable Circular Orbit mean?

The innermost stable circular orbit (often called the ISCO) is the smallest marginally stable circular orbit in which a test particle can stably orbit a massive object in general relativity. The location of the ISCO, the ISCO-radius ( r i s c o {\displaystyle r_{\mathrm {isco} }} ), depends on the angular momentum (spin) of the central object.

The ISCO plays an important role in black hole accretion disks since it marks the inner edge of the disk.

reference

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