OTC meaning in Medical ?

Answer: What is Ornithine Transcarbamylase Deficiency mean?

Ornithine transcarbamylase deficiency also known as OTC deficiency is the most common urea cycle disorder in humans. Ornithine transcarbamylase, the defective enzyme in this disorder is the final enzyme in the proximal portion of the urea cycle, responsible for converting carbamoyl phosphate and ornithine into citrulline. OTC deficiency is inherited in an X-linked recessive manner, meaning males are more commonly affected than females.

In severely affected individuals, ammonia concentrations increase rapidly causing ataxia, lethargy and death without rapid intervention. OTC deficiency is diagnosed using a combination of clinical findings and biochemical testing, while confirmation is often done using molecular genetics techniques.

Once an individual has been diagnosed, the treatment goal is to avoid precipitating episodes that can cause an increased ammonia concentration. The most common treatment combines a low protein diet with nitrogen scavenging agents. Liver transplant is considered curative for this disease. Experimental trials of gene therapy using adenoviral vectors resulted in the death of one participant, Jesse Gelsinger, and have been discontinued.

reference

Full Form	Category
Occupational Training Center	Academic & Science
Ogeechee Technical College	Academic & Science
Bol	Airport Code
Over the Counter	Banking
Osaka Titanium Technologies	Business
Ortac Resources, LTD.	Business
Open Text Corporation	Business
Otoc Limited	Business
Open Text Corp	Business
Owatonna Tool Company	Business
Operation and Transport Corporation	Business
On Target Commission	Business
OnTrack Consulting	Business
Online Travel Company	Business
Outside Threaded Container	Business
Open Tubular Column	Chemistry
Offshore Technology Conference	Community
Ozarks Technical Community	Community
Outreach Throughout the Community	Community
One True Church	Community
Our Time Cabaret	Community
Original Trilogy Collection	Community
One Team Conference	Community
Olney Theatre Center	Community
Overflow of Tacho Counter	Computer Assembly Language
Offshore Technology Conferences	Computing
Operations Technical Center	Computing
Over The Cell	Computing
Optimization Technology Center	Computing
Ohio Technical College	Educational Institute
Okefenokee Technical College	Educational Institute
Output Transformer Coupled	Electronics
Ozone Transport Commission	General
On the Counter	General
On The Con	General
Open Transparent and Connected	General
Oh Those Clowns	General
Order Through Chaos	General
On The Cool	General
Orbiter Test Conductors	General
Off The Chart(s)	General
Online Training Center	General
Ocean Thematic Centre	General
Oldtimer Center	General
Other Than Collision	General
On The Car	General
Overhead Trip Computer	General
Oklahoma Truck Club	General
Ontario Triumph Club	General
Oldtimer Club	General
Ohio Transportation Consortium	General
Original Teile Center	General
Other Than Clinton	General
Ocean Systems Technician Chief Petty Officer	Governmental
Overseas Telecommunications Commission	Governmental
Officers Training Conference	Governmental
Oklahoma Tax Commission	Governmental
Oregon Transportation Commission	Governmental
Offender Time Computation	Governmental
Online Teen Club	Internet
Ornithine Transcarbamylase	Medical
Ornithine Transcarbamylase Deficiency	Medical
Off Topic Comments	Messaging
Operational Test Command	Military and Defence
Officer Training Corps	Military and Defence
Officer In Tactical Command	Military and Defence
On-going Test Case	Softwares
Orbiter Test Conductor	Space Science
Other Tennis Club	Sports
Olympic Training Center	Sports
On The Clock	Sports
Optical Telephone Corporation	Stock Exchange
Office of Technology Commercialization	Technology
One-time Charge	Telecommunication
Operating Telephone Company	Telecommunication