PRF meaning in Medical ?

Answer:

What is Platelet-rich fibrin mean?

Platelet-rich fibrin (PRF) or leukocyte- and platelet-rich fibrin (L-PRF) is a second-generation PRP where autologous platelets and leukocytes are present in a complex fibrin matrix to accelerate the healing of soft and hard tissue and is used as a tissue-engineering scaffold for endodontics. To obtain PRF, required quantity of blood is drawn quickly into test tubes without an anticoagulant and centrifuged immediately. Blood can be centrifuged using a tabletop centrifuge from 3-8 minutes for 1300 revolutions per minute. The resultant product consists of the following three layers; topmost layer consisting of platelet poor plasma, PRF clot in the middle, and red blood cells (RBC) at the bottom. PRF is available as a fibrin clot. PRF clot can be removed from the test tube using a sterile tweezer-like instrument. After lifting, the RBC layer attached to the PRF clot can be carefully removed using a sterilized scissor. Platelet activation in response to tissue damage occurs during the process of making PRF release several biologically active proteins including; platelet alpha granules, platelet‑derived growth factor (PGDF), transforming growth factors‑β (TGF‑β), vascular endothelial growth factor (VEGF), and epidermal growth factor. Actually, the platelets and leukocyte cytokines play important parts in role of this biomaterial, but the fibrin matrix supporting them is the most helpful in constituting the determining elements responsible for real therapeutic potential of PRF. Cytokines are immediately used and destroyed in a healing wound. The harmony between cytokines and their supporting fibrin matrix has much more importance than any other platelet derivatives.

reference

Full Form	Category
Pseudo-Random Function	Academic & Science
Petroleum Research Fund	Academic & Science
Postdoctoral Research Fellowships	Academic & Science
Poliomyelitis Research Foundation	Academic & Science
Personality Research Form	Academic & Science
Patient Record Flags	Academic & Science
Pain Research Forum	Academic & Science
Protein Research Foundation	Academic & Science
Port Johnson (ak)	Airport Code
Provider Relief Fund	Business
Premier Rock Forum	Community
Premiere Rock Forum	Community
Pacific Rim Forum	Community
Plastics Reclamation Facility	Community
Pixel Run Format	Computing
Pics Rules File	Computing
Improces - Fastgraph Pixel Run Format Bitmap Graphics	File Type
Checkit Pro 1.0 Data File	File Type
Dbase Iv Printer Driver File	File Type
Profiler Output	File Type
Plastics Recovery Facility	General
Plate Ready Film	General
Punk Revolution Freedom	General
Peninsula Radio Flyers	General
Principal Reference Frame	General
Purdue Research Foundation	General
Progeria Research Foundation	General
Pasture Rangeland and Forage	General
Pasture Rangeland Forage	General
Positive Real Function	General
Pulse Repitition Frequency	General
Plasma Rich Fibrin	General
Polícia Rodoviária Federal	General
Power Return Factor	General
Pedigree Resource File	General
Personnel Record Form	General
Program Registration Form	General
Population Receptive Field	General
Plastico Reforcado Com Fibra	General
Producer Recycling Fund	Governmental
Pollution Recovery Fund	Governmental
PARSIPUR	Indian Railway Station
Pseudomonas Resistance and Fenthion	Medical
Platelet-rich fibrin	Medical
Personnel Resources File	Military and Defence
Port Johnson, Alaska USA	Regional
Parachute Refurbishment Facility	Space Science
Pulse Repetition Frequency	Space Science