SCID meaning in Disease ?

Answer: What is Severe Combined Immunodeficiency Disease mean?

Severe combined immunodeficiency (SCID), also known as Swiss-type agammaglobulinemia, is a rare genetic disorder characterized by the disturbed development of functional T cells and B cells caused by numerous genetic mutations that result in differing clinical presentations. SCID involves defective antibody response due to either direct involvement with B lymphocytes or through improper B lymphocyte activation due to non-functional T-helper cells. Consequently, both "arms" (B cells and T cells) of the adaptive immune system are impaired due to a defect in one of several possible genes. SCID is the most severe form of primary immunodeficiencies, and there are now at least nine different known genes in which mutations lead to a form of SCID. It is also known as the bubble boy disease and bubble baby disease because its victims are extremely vulnerable to infectious diseases and some of them, such as David Vetter, have become famous for living in a sterile environment. SCID is the result of an immune system so highly compromised that it is considered almost absent.

SCID patients are usually affected by severe bacterial, viral, or fungal infections early in life and often present with interstitial lung disease, chronic diarrhea, and failure to thrive. Ear infections, recurrent Pneumocystis jirovecii (previously carinii) pneumonia, and profuse oral candidiasis commonly occur. These babies, if untreated, usually die within one year due to severe, recurrent infections unless they have undergone successful hematopoietic stem cell transplantation or gene therapy in clinical trials.

reference

Full Form	Category
Systematic Curriculum and Instructional Development	Community
Stanford Center for International Development	Community
Shane's Chess Information Database	Computing
Scheduling Coordinator Identification	Computing
Severe Combined Immunodeficiency Disease	Disease
Sample Collection Information Documents	General
Severe Combined Immune Deficient	General
Severe Combined Immune Deficiency	General
Social Complexity of Immigration and Diversity	Governmental
Source Code in Database	Information Technology
Structured Clinical Interview for DSM	Medical
Severe Combined Immunodeficiency Disorder	Medical
Spacecraft Identification	Space Science