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What is Troponin I mean?
Troponin I is a cardiac and skeletal muscle protein family. It is a part of the troponin protein complex, where it binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Troponin I prevents myosin from binding to actin in relaxed muscle. When calcium binds to the troponin C, it causes conformational changes which lead to dislocation of troponin I. Afterwards, tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. The letter I is given due to its inhibitory character. It is a useful marker in the laboratory diagnosis of heart attack. It occurs in different plasma concentration but the same circumstances as troponin T - either test can be performed for confirmation of cardiac muscle damage and laboratories usually offer one test or the other.
Three paralogs with unique tissue-specific expression patterns are expressed in humans, listed below with their locations and OMIM accessions:
Slow-twitch skeletal muscle isoform troponin I, TNNI1 (1q31.3, 191042)Fast-twitch skeletal muscle isoform troponin I, TNNI2 (11p15.5, 191043)Cardiac troponin I, TNNI3 (19q13.4, 191044) referencePosted on 09 Jan 2025, this text provides information on Miscellaneous in Medical related to Medical. Please note that while accuracy is prioritized, the data presented might not be entirely correct or up-to-date. This information is offered for general knowledge and informational purposes only, and should not be considered as a substitute for professional advice.
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