Colleton County High School (formed from the merging of Walterboro High School and Ruffin High School) is a public high school in Walterboro, South Carolina, United States. It is the only public high school in Colleton County and is one of the largest high schools by enrollment in the state, despite being located in a mostly rural county. It is a part of the Colleton County School District. The school is led by principal Maurice Cannon.
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