Children's Medical Research Institute (CMRI) is an Australian-based independent medical research institute located in Westmead, Sydney NSW that conducts research into children's genetic diseases. As of 2019, current research is focused on cancer, birth defects, neurological conditions such as epilepsy, and gene therapy to treat genetic diseases. CMRI created and continues to operate Australia's Jeans for Genes fundraising campaign.
CMRI was founded in 1958 by paediatricians Sir Lorimer Dods, Dr John Fulton and Douglas Burrows, honorary treasurer and later president of the Royal Alexandra Hospital for Children, to "perform scientific research with a commitment to better treat, and where possible, prevent childhood illness and disability so that all concerned have a better quality of life".
Much of CMRI's cancer research focuses on telomeres (including telomerase) and the Alternative Lengthening of Telomeres (ALT) mechanism, which was discovered at CMRI in 1997. In 2016, CMRI launched an international project to develop a big data approach to personalised, precision medicine called ProCan. Seed funding of $10 million was obtained for ProCan from the Australian Cancer Research Foundation (ACRF), and has since been funded by the Australian Government, NSW State Government and other organisations. The project is now part of the US Cancer Moonshot through ICPC and the European iPC project.
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