Inflammatory demyelinating diseases (IDDs), sometimes called Idiopathic (IIDDs) because the unknown etiology of some of them, and sometimes known as borderline forms of multiple sclerosis, is a collection of multiple sclerosis variants, sometimes considered different diseases, but considered by others to form a spectrum differing only in terms of chronicity, severity, and clinical course.
Multiple sclerosis for some people is a syndrome more than a single disease. As of 2019, three auto-antibodies have been found in atypical MS giving birth to separate diseases: Anti-AQP4 diseases, Anti-MOG and Anti-NF spectrums. Also a LHON-associated MS has been reported, as well as the medication-induced anti-TNF spectrum (which cannot be distinguished from natural MS with the current knowledge) can be included here.
The subject is under intense research and the list of MS autoantibodies is expected to grow in the near future
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