NBIA meaning in Medical ?

Answer: What is Neurodegeneration with brain iron accumulation mean?

Neurodegeneration with brain iron accumulation is a heterogenous group of inherited neurological disorders, still under research, in which iron accumulates in the basal ganglia, either resulting in progressive dystonia, Parkinsonism, spasticity, optic atrophy, retinal degeneration, neuropsychiatric, or diverse neurologic abnormalities.Some of the NBIA disorders have also been associated with several genes in synapse and lipid metabolism related pathways. NBIA is not one disease but an entire group of disorders, characterized by an accumulation of brain iron, sometimes in the presence of axonal spheroids in the central nervous system. Iron accumulation can occur anywhere in the brain, with accumulation typically occurring in globus pallidus, substantia nigra, pars reticula, striatum and cerebellar dentate nuclei. Symptoms can include various movement disorders, neuropsychiatric issues, seizures, visual disturbances, and cognitive decline, usually in different combinations. The cause of NBIA disorders are a multitude of possible mutations in genes directly involved in iron metabolism, and/or impaired phospholipid, and/or ceramide metabolism, and/or lysosomal disorders, as well as mutations in genes with unknown functions. Onset can occur at different ages, from early childhood to late adulthood.

reference

Full Form	Category
Niels Bohr International Academy	Academic & Science
New Business Initiative Approval	Business
National Business Incubation Association	Community
Normandy Beach Improvement Association	Community
National Baking Industry Association	Community
Northern Brain Injury Association	Community
Neurodegenerative Brain Iron Accumulation	General
North Bali International Airport	International
Neurodegeneration with brain iron accumulation	Medical
National Biomedical Imaging Archive	Medical