Optical coherence tomography angiography (OCTA) is a non-invasive imaging technique known as optical coherence tomography (OCT) developed to visualize vascular networks in the human retina, choroid, skin and various animal models. OCTA may make use of speckle variance optical coherence tomography.
OCTA uses low-coherence interferometry to measure changes in backscattered signal to differentiate areas of blood flow from areas of static tissue. To correct for patient movement during scanning, bulk tissue changes in the axial direction are eliminated, ensuring that all detected changes are due to red blood cell movement. This form of OCT requires a very high sampling density in order to achieve the resolution needed to detect the tiny capillaries found in the retina. Recent advancements in OCT acquisition speed have made it possible the required sampling density to obtain a high enough resolution for OCTA. This has allowed OCTA to become widely used clinically to diagnose a variety of ophthalmological diseases, such as, age related macular degeneration (AMD), diabetic retinopathy, artery and vein occlusions, and glaucoma.
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