PAIS meaning in Medical ?

Answer: What is Partial Androgen Insensitivity Syndrome mean?

Partial androgen insensitivity syndrome (PAIS) is a condition that results in the partial inability of the cell to respond to androgens. It is an X linked recessive condition. The partial unresponsiveness of the cell to the presence of androgenic hormones impairs the masculinization of male genitalia in the developing fetus, as well as the development of male secondary sexual characteristics at puberty, but does not significantly impair female genital or sexual development. As such, the insensitivity to androgens is clinically significant only when it occurs in individuals with a Y chromosome (or more specifically, an SRY gene). Clinical features include ambiguous genitalia at birth and primary amenhorrhoea with clitoromegaly with inguinal masses. Mullerian structures are not present in the individual.

PAIS is one of three types of androgen insensitivity syndrome, which is divided into three categories that are differentiated by the degree of genital masculinization: complete androgen insensitivity syndrome (CAIS) is indicated when the external genitalia is that of a typical female, mild androgen insensitivity syndrome (MAIS) is indicated when the external genitalia is that of a typical male, and partial androgen insensitivity syndrome (PAIS) is indicated when the external genitalia is partially, but not fully masculinized.

Androgen insensitivity syndrome is the largest single entity that leads to 46,XY undermasculinization.

There are differing opinions on whether treatment is necessary. Treatment may include irreversible and far reaching surgical operations such as gonadectomy, as well as hormone replacement therapy, or vaginoplasty if the patient has desire to engage in penetrative sex.

reference

Full Form	Category
Photo Acoustic Infrared Spectroscopy	Academic & Science
Psychological Adjustment To Illness Scale	Academic & Science
Personal Accident Insurance Schism	Business
Pennsylvania Association of Independent Schools	Community
Prestigious Applications Of Intelligent Systems	Computing
Physicians Appointment Information System	Computing
Public Access Internet Site	Computing
Path Alarm Indicator Signal	Computing
Panasonic Automotive and Industrial Systems	General
People-Carrier Automotive Investment Scheme	General
Politics and International Studies	General
Patient Active Inactive Status	General
Practice Accreditation And Improvement Survey	General
Path Alarm Indication Signal	General
Pa Adelanto i Inovashon Soshal	General
Patria Altiva I Soberana	General
Public Affairs and Information Staff	Governmental
Public Affairs Information Service	Governmental
PAN Asia International School	International
Partial Androgen Insensitivity Syndrome	Medical
Primary Androgen Insensitivity Syndrome	Medical