Tris(2-pyridylmethyl)amine (abbreviated TPMA or TPA) is an organic compound with the formula (C5H4NCH2)3N. It is a tertiary amine with three picolyl substituents. It is a white solid that is soluble in polar organic solvents. It is a ligand in coordination chemistry.
The ligand is prepared by the alkylation of 2-picolylamine by picolyl chloride:
2 C5H4NCH2Cl + C5H4NCH2NH2 → (C5H4NCH2)3N + 2 HClTPMA is a tripodal ligand, often used to simulate the coordination environment within some proteins. It is also used as a copper ligand in ATRP.
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